Nm23-H1 was involved in regulation of KAI1 expression in high-metastatic lung cancer cells L9981
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چکیده
منابع مشابه
Relationship between the expression of miR137 in the serum of patients with metastatic lung cancer
Background: Micro-Ribonocellic Acids (miRNA) are non-coding nucleic acids that are evolutionally protected and have a length of 24-20 nucleotides. MiRNAs control the expression of genes after transcription by mRNA degradation or translation inhibition. By blocking the oncogenic miRNAs and creating the necessary and functional miRNAs (tumor suppressor), these small regulatory RNAs can have thera...
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متن کاملnm23-H1 expression and loss of heterozygosity in colon adenocarcinoma.
BACKGROUND The discovery that genetic alterations in oncogenes and tumour suppressor genes accompany tumour formation in many human tumours has encouraged the search for genes that promote or suppress tumour spread and metastasis; nm23 is a promising candidate for a metastasis suppressing gene. AIMS To evaluate whether expression of nm23-H1 protein or loss of heterozygosity (LOH) of the nm23-...
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nm23-H1, a nucleoside diphosphate kinase (NDPK), enhances drug sensitivity and has antimetastatic activity, whereas focal adhesion kinase (FAK) is closely associated with cell migration and tumour spreading. The relationship between these two proteins, however, is not well elucidated. In this study, we investigate their correlation in patients with non-small cell lung cancer (NSCLC). Expression...
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ژورنال
عنوان ژورنال: Journal of Thoracic Disease
سال: 2016
ISSN: 2072-1439,2077-6624
DOI: 10.21037/jtd.2016.04.59